MTV’s Musical March Madness: Panic! At The Disco Vs. Avril Lavigne, Florence And The Machine Vs. Brandon Flowers

It’s MTV’s second annual Musical March Madness! MTV News took the 64 biggest names in rock, split them up into four regions, assigned them seeds and puts them up against one another in a single-elimination series of match-ups in a winner-take-all contest. We’re leaving it to you to decide an actual champ in this field of 64, so over the next few weeks, fan voting will determine who will emerge as this year’s champion. It’s all about the fans, and the artist with the most passionate fan base will score the awesome Musical March Madness trophy!

The voting continues in the West bracket, with 30 Seconds to Mars jumping out to an early lead over Yellowcard and Pearl Jam and Train trading blows in a tight early race. There are two more match-ups below between some real heavy hitters, which should keep the action hot.

As always, first round voting continues through Sunday night (March 20), and you can catch up with any match-ups you might have missed here.

(5) Panic! at the Disco vs. (12) Avril Lavigne
Panic! at the Disco have climbed back to the upper echelons of the rock world with their hotly-anticipated new album Vices & Virtues. The group’s third release already has one hit single in “The Ballad of Mona Lisa,” with more to come when the album finally hits the streets on March 22. They square off against a feisty Avril Lavigne, who is back on the scene with an excellent new album Goodbye Lullaby. Will the chart dominance of “What the Hell” be enough to topple the Panic boys? Only you can decide!

(4) Florence and the Machine vs. (13) Brandon Flowers
Florence & the Machine have climbed up the rock ladder thanks to a number of high profile TV performances and the greatness of “Dog Days Are Over.” Meanwhile, Brandon Flowers put out one of the most underrated albums of 2010 in Flamingo and is primed for another run to the top of the rock world. Who will emerge victorious? Your votes will decide it!

Watch Dick Bagwell and Vincent Twice break down this year’s bracket!

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Check out the Musical March Madness bracket and be take a look at the hoops-centric photos of some of the tournament’s biggest bands.